Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Infection of cells by microorganisms activates the inflammatory response. The initial sensing
of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll …

In terms of both phenotype and function, macrophages have remarkable heterogeneity,
which reflects the specialization of tissue-resident macrophages in microenvironments as …

Glutamine metabolism provides synergistic support for macrophage activation and elicitation
of desirable immune responses; however, the underlying mechanisms regulated by …

Epigenetic regulation of gene expression is a dynamic and reversible process that
establishes normal cellular phenotypes but also contributes to human diseases. At the …

A number of widespread and devastating chronic diseases, including atherosclerosis, type 2
diabetes, and Alzheimer's disease, have a pathophysiologically important inflammatory …

Polarization of macrophages to M1 or M2 cells is important for mounting responses against
bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a …

The jumonji (JMJ) family of histone demethylases are Fe2+-and α-ketoglutarate-dependent
oxygenases that are essential components of regulatory transcriptional chromatin …

Histone modifications are thought to regulate chromatin structure, transcription and other
nuclear processes. Histone methylation was originally believed to be an irreversible …