The multipotent mesenchymal stem/stromal cells (MSCs), initially discovered from bone
marrow in 1976, have been identified in nearly all tissues of human body now. The …

Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

Transitory phenotypic changes such as the epithelial–mesenchymal transition (EMT) help
embryonic cells to generate migratory descendants that populate new sites and establish …

Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

Obesity is known to have important roles in driving prostate cancer aggressiveness and
increased mortality. Multiple mechanisms have been postulated for these clinical …

The tumour microenvironment consists of a complex mixture of non‐neoplastic cells,
including fibroblasts, immune cells and endothelial cells embedded in the proteins of the …

Colorectal cancer is considered one of the major malignancies that threaten the lives and
health of people around the world. Patients with CRC are prone to post-operative local …

Current treatments for chronic pain, such as inflammatory pain, neuropathic pain, and
cancer pain are insufficient and cause severe side effects. Mounting evidence suggests that …

Mesenchymal stromal cells (MSCs) are important cellular constituents of tumor stroma that
play an active role in tumor development. Complex interactions between MSCs and cancer …