[HTML][HTML] Cone snails: A big store of conotoxins for novel drug discovery

B Gao, C Peng, J Yang, Y Yi, J Zhang, Q Shi - Toxins, 2017 - mdpi.com
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …

Nicotinic acetylcholine receptor inhibitors derived from snake and snail venoms

S Dutertre, A Nicke, VI Tsetlin - Neuropharmacology, 2017 - Elsevier
The nicotinic acetylcholine receptor (nAChR) represents the prototype of ligand-gated ion
channels. It is vital for neuromuscular transmission and an important regulator of …

Whole genome duplication and gene evolution in the hyperdiverse venomous gastropods

S Farhat, MV Modica, N Puillandre - Molecular Biology and …, 2023 - academic.oup.com
The diversity of venomous organisms and the toxins they produce have been increasingly
investigated, but taxonomic bias remains important. Neogastropods, a group of marine …

Non-consumptive effects in fish predator–prey interactions on coral reefs

MD Mitchell, AR Harborne - Coral Reefs, 2020 - Springer
Predator–prey interactions are critical in ecological communities, but it is increasingly clear
that a predator's effect goes beyond eating prey. Fear of predators may also alter the …

[HTML][HTML] Nicotinic acetylcholine receptor subtype expression, function, and pharmacology: therapeutic potential of α-conotoxins

HS Tae, DJ Adams - Pharmacological Research, 2023 - Elsevier
The pentameric nicotinic acetylcholine receptors (nAChRs) are typically classed as muscle-
or neuronal-type, however, the latter has also been reported in non-neuronal cells. Given …

Predatory and defensive strategies in cone snails

Z Ratibou, N Inguimbert, S Dutertre - Toxins, 2024 - mdpi.com
Cone snails are carnivorous marine animals that prey on fish (piscivorous), worms
(vermivorous), or other mollusks (molluscivorous). They produce a complex venom mostly …

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

P Ahorukomeye, MM Disotuar, J Gajewiak, S Karanth… - Elife, 2019 - elifesciences.org
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to
induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins …

Bibliometric review of the literature on cone snail peptide toxins from 2000 to 2022

LTT Nguyen, DJ Craik, Q Kaas - Marine drugs, 2023 - mdpi.com
The venom of marine cone snails is mainly composed of peptide toxins called conopeptides,
among which conotoxins represent those that are disulfide-rich. Publications on …

Oxytocin mediated behavior in invertebrates: An evolutionary perspective

MA Lockard, MS Ebert… - Developmental …, 2017 - Wiley Online Library
The molecular and functional conservation of oxytocin‐related neuropeptides in behavior is
striking. In animals separated by at least 600 million years of evolution, from roundworms to …

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

IBL Ramiro, WE Bjørn-Yoshimoto, JS Imperial… - Science …, 2022 - science.org
Somatostatin (SS) is a peptide hormone with diverse physiological roles. By investigating a
deep-water clade of fish-hunting cone snails, we show that predator-prey evolution has …