Computational techniques for ECG analysis and interpretation in light of their contribution to medical advances
Widely developed for clinical screening, electrocardiogram (ECG) recordings capture the
cardiac electrical activity from the body surface. ECG analysis can therefore be a crucial first …
cardiac electrical activity from the body surface. ECG analysis can therefore be a crucial first …
[HTML][HTML] Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …
components across multiple spatial (from ion channel to organ) and temporal (from …
[HTML][HTML] A framework for the generation of digital twins of cardiac electrophysiology from clinical 12-leads ECGs
Abstract Cardiac digital twins (Cardiac Digital Twin (CDT) s) of human electrophysiology
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
(Electrophysiology (EP)) are digital replicas of patient hearts derived from clinical data that …
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
Human-based modelling and simulations are becoming ubiquitous in biomedical science
due to their ability to augment experimental and clinical investigations. Cardiac …
due to their ability to augment experimental and clinical investigations. Cardiac …
[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach
T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …
medicine and support clinical decision making by providing a powerful tool to understand …
[HTML][HTML] Digital twinning of the human ventricular activation sequence to Clinical 12-lead ECGs and magnetic resonance imaging using realistic Purkinje networks for …
Cardiac in silico clinical trials can virtually assess the safety and efficacy of therapies using
human-based modelling and simulation. These technologies can provide mechanistic …
human-based modelling and simulation. These technologies can provide mechanistic …
[HTML][HTML] Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy
Background Pseudonormal T waves may be detected on stress electrocardiograms (ECGs)
in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise …
in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise …
MRI-based computational torso/biventricular multiscale models to investigate the impact of anatomical variability on the ECG QRS complex
Aims Patient-to-patient anatomical differences are an important source of variability in the
electrocardiogram, and they may compromise the identification of pathological …
electrocardiogram, and they may compromise the identification of pathological …
[HTML][HTML] Inference of ventricular activation properties from non-invasive electrocardiography
The realisation of precision cardiology requires novel techniques for the non-invasive
characterisation of individual patients' cardiac function to inform therapeutic and diagnostic …
characterisation of individual patients' cardiac function to inform therapeutic and diagnostic …
Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction
Aims Develop, calibrate and evaluate with clinical data a human electromechanical
modelling and simulation framework for multiscale, mechanistic investigations in healthy …
modelling and simulation framework for multiscale, mechanistic investigations in healthy …