Mutations in the GNAO1 gene cause a complex constellation of neurological disorders
including epilepsy, developmental delay, and movement disorders. GNAO1 encodes Gα o …

There are various types of receptors in the central nervous system (CNS). G protein-coupled
receptors (GPCRs) have the highest expression with a wide range of physiological …

Optogenetic and chemogenetic actuators are critical for deconstructing the neural correlates
of behavior. However, these tools have several limitations, including invasive modes of …

Food addiction is linked to obesity and eating disorders and is characterized by a loss of
behavioral control and compulsive food intake. Here, using a food addiction mouse model …

Ribosome tagging has become a very useful in vivo approach for analyzing gene
expression and mRNA translation in specific cell types that are difficult and time consuming …

GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the
striatum and regulates diverse brain and behavioral functions. Here we present cryo-EM …

While the precise processes underlying a sex bias in the development of central nervous
system (CNS) disorders are unknown, there is growing evidence that an early life immune …

In neuropsychiatry, animal studies demonstrating causal effects of environmental
manipulations relevant to human aetiology on behaviours relevant to human …

Traditional antidepressants largely interfere with monoaminergic transport or degradation
systems, taking several weeks to have their therapeutic actions. Moreover, a large …

Hypothalamic neuronal populations are central regulators of energy homeostasis and
reproductive function. However, the ontogeny of these critical hypothalamic neuronal …