The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases
The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …
role in regulating immune responses provided a deeper understanding of self-tolerance …
Tissue regulatory T cells: regulatory chameleons
Abstract The FOXP3+ CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have …
[HTML][HTML] Immune microniches shape intestinal Treg function
The intestinal immune system is highly adapted to maintaining tolerance to the commensal
microbiota and self-antigens while defending against invading pathogens,. Recognizing …
microbiota and self-antigens while defending against invading pathogens,. Recognizing …
TCF1 in T cell immunity: a broadened frontier
TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …
downstream of the WNT signalling pathway and are essential for early T cell development …
[PDF][PDF] Bacteria‐based cancer immunotherapy
X Huang, J Pan, F Xu, B Shao, Y Wang… - Advanced …, 2021 - Wiley Online Library
In the past decade, bacteria‐based cancer immunotherapy has attracted much attention in
the academic circle due to its unique mechanism and abundant applications in triggering the …
the academic circle due to its unique mechanism and abundant applications in triggering the …
[HTML][HTML] An atlas of cells in the human tonsil
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …
immunological defense against inhaled or ingested pathogens. We generated an atlas of …
T cell factor 1: A master regulator of the T cell response in disease
Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …
development and T memory formation and encompasses new functions in the regulation of …
Microbiota-derived butyrate limits the autoimmune response by promoting the differentiation of follicular regulatory T cells
Background Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder with a
high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota …
high prevalence, especially in industrialized countries. Dysbiosis of the intestinal microbiota …
The dynamic shifts of IL-10-producing Th17 and IL-17-producing Treg in health and disease: a crosstalk between ancient" Yin-Yang" theory and modern immunology
The changes in T regulatory cell (Treg) and T helper cell (Th) 17 ratios holds paramount
importance in ensuring internal homeostasis and disease progression. Recently, novel …
importance in ensuring internal homeostasis and disease progression. Recently, novel …
Regulatory T cells in peripheral tissue tolerance and diseases
Maintenance of peripheral tolerance by CD4+ Foxp3+ regulatory T cells (Tregs) is essential
for regulating autoreactive T cells. The loss of function of Foxp3 leads to autoimmune …
for regulating autoreactive T cells. The loss of function of Foxp3 leads to autoimmune …