Abstract The Rho GTPases—RHOA, RAC1 and CDC42—are small GTP binding proteins
that regulate basic biological processes such as cell locomotion, cell division and …

Optogenetics combines light and genetics to enable precise control of living cells, tissues,
and organisms with tailored functions. Optogenetics has the advantages of …

During the intricate process by which cells give rise to tissues, embryonic and adult stem
cells are exposed to diverse mechanical signals from the extracellular matrix (ECM) that …

Migration of endothelial and many other cells requires spatiotemporal regulation of
protrusive and contractile cytoskeletal rearrangements that drive local cell shape changes …

RhoGTPases are well known for being controllers of cell cytoskeleton and share common
features in the way they act and are controlled. These include their switch from GDP to GTP …

The actomyosin cortex is an active material that generates force to drive shape changes via
cytoskeletal remodeling. Cytokinesis is the essential cell division event during which a …

The actin cortex is an active adaptive material, embedded with complex regulatory networks
that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range …

In addition to biochemical and electrochemical signaling, cells also rely extensively on
mechanical signaling to regulate their behavior. While a number of tools have been adapted …

In textbook illustrations of migrating cells, actomyosin contractility is typically depicted as the
contraction force necessary for cell body retraction. This dogma has been transformed by the …

Rho GTPases play a key role in the spatio-temporal coordination of cytoskeletal dynamics
during cell migration. Here, we directly investigate crosstalk between the major Rho …