Is chronic pain caused by central sensitization? A review and critical point of view

E Velasco, M Flores-Cortes, J Guerra-Armas… - Neuroscience & …, 2024 - Elsevier
Chronic pain causes disability and loss of health worldwide. Yet, a mechanistic explanation
for it is still missing. Frequently, neural phenomena, and among them, Central Sensitization …

Chronic temporomandibular disorders are associated with higher propensity to develop central sensitization: a case–control study

T Cayrol, EN van den Broeke, E Gerard, M Meeus… - Pain, 2023 - journals.lww.com
Temporomandibular disorders (TMD) include a group of musculoskeletal disorders that may
involve increased responsiveness of nociceptive neurons in the central nervous system (ie …

[HTML][HTML] Sensory profiles predict symptoms of central sensitization in low back pain: a predictive model research study

PJ Gräper, A Scafoglieri, JR Clark… - Journal of clinical …, 2024 - mdpi.com
Background: Acute low back pain has a high prevalence, and when persisting into
chronicity, it results in enormous socio-economic consequences. Sensory preferences may …

Evidence for alterations to dynamic quantitative sensory tests in patients with chronic temporomandibular myalgia: a systematic review of observational studies with …

T Cayrol, M Meeus, V Aron, C Gatto… - Journal of oral …, 2022 - Wiley Online Library
Background Conflicting results exist between somatosensory profiles of patients with
temporomandibular myalgia (TMDm). The objective of this review was to examine whether …

Sensory profiles and their role in the persistence of central sensitization symptoms in low back pain. A prospective cohort study

PJ Gräper, J Hartvigsen, A Scafoglieri… - … Theory and Practice, 2025 - Taylor & Francis
Introduction Acute lower back pain can lead to neuroplastic changes in the central nervous
system, and symptoms of central sensitization after 12 weeks. While sensory sensitivity has …

Characteristics and Outcomes of Patients Receiving Physical Therapy for Low Back Pain with a Nociplastic Pain Presentation: A Secondary Analysis

AT Wilson, JL Riley, MD Bishop… - Pain Research and …, 2023 - Wiley Online Library
Introduction. Individuals with low back pain (LBP) may be classified based on mechanistic
descriptors, such as a nociplastic pain presentation (NPP). The purpose of this secondary …

The comparison between the effects of pain education interventions with online and face-to-face exercise and the control group received biomedical education+ …

Z Khosrokiani, A Letafatkar, M Hadadnezhad… - Trials, 2022 - Springer
Background Various psychological issues and serious health concerns during the imposed
lockdown by coronavirus disease 2019 (COVID-19) have induced many changes in the …

[HTML][HTML] Temporal relationships between pain, functioning, and human assumed central sensitization in patients with chronic low back pain; a single-case design

AN Bennema, HRS Preuper, LA Krops… - … Science and Practice, 2024 - Elsevier
Background Interdisciplinary pain rehabilitation (IPR) aims to improve functioning in people
with chronic low back pain (CLBP), and is not primary aimed at pain reduction. Many …

The Association Between the Patient Self-Report Survey for the Assessment of Fibromyalgia with Pain Sensitivity and Psychological Factors in Individuals with …

AT Wilson, C Razzell, WJ Hanney - Journal of pain research, 2023 - Taylor & Francis
Purpose The Patient Self-Report Survey for the Assessment of Fibromyalgia may potentially
be a method for subgrou** patients with musculoskeletal pain who have a nociplastic pain …

[HTML][HTML] Sex-Specific Sensory Profiles Discriminate Between Sensitization at Twelve Weeks in Patients with Acute Low Back Pain: A Retrospective Study

PJ Gräper, A Scafoglieri, JM Hallegraeff - Journal of Clinical Medicine, 2025 - mdpi.com
Background/objective: Low back pain (LBP) is the leading cause of disability worldwide,
resulting in enormous socio-economic and personal consequences. Sensory profiles during …