Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Ubiquitination is one of the most important post‐translational modifications which plays a
significant role in conserving the homeostasis of cellular proteins. In the ubiquitination …

The mitogen-activated protein kinase (MAPK) signaling pathway is the primary regulatory
module of various cellular processes such as cell proliferation, differentiation, and stress …

The ubiquitin-proteasome axis has been extensively explored at a system-wide level, but the
impact of deubiquitinating enzymes (DUBs) on the ubiquitinome remains largely unknown …

Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

Activation of tumor-intrinsic innate immunity has been a major strategy for improving
immunotherapy. Previously, we reported an autophagy-promoting function of the …

Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …

Sortase A (SrtA)‐mediated ligation, a popular method for protein labeling and semi‐
synthesis, is limited by its reversibility and dependence on the LPxTG motif, where “x” is any …

The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that
switch from inactive to activated conformations upon site-specific cullin modification by the …