Molecular rotors: fluorescent sensors for microviscosity and conformation of biomolecules

M Paez‐Perez, MK Kuimova - Angewandte Chemie, 2024 - Wiley Online Library
The viscosity and crowding of biological environment are considered vital for the correct
cellular function, and alterations in these parameters are known to underly a number of …

Fatty acids in cancer chemoresistance

J Qin, L Ye, X Wen, X Zhang, Y Di, Z Chen, Z Wang - Cancer Letters, 2023 - Elsevier
Despite the remarkable clinical success of immunotherapy and molecular targeted therapy
in patients with advanced tumors, chemotherapy remains the most commonly used …

Selective visualization of tumor cell membranes and tumors with a viscosity-sensitive plasma membrane probe

Q Li, W Zhu, S Gong, S Jiang, G Feng - Analytical Chemistry, 2023 - ACS Publications
Cancer is a worldwide health problem. Revealing the changes in the microenvironment after
cell carcinogenesis is helpful to understand cancer and develop sensitive methods for …

Polarity-sensitive and membrane-specific probe quantitatively monitoring ferroptosis through fluorescence lifetime imaging

S Wu, Y Yan, H Hou, Z Huang, D Li, X Zhang… - Analytical …, 2022 - ACS Publications
As a new form of regulated cell death, ferroptosis is closely related to various diseases. To
interpret this biological behavior and monitor related pathological processes, it is necessary …

Sensing cholesterol-induced rigidity in model membranes with time-resolved fluorescence spectroscopy and microscopy

B Biswas, D Shah, SJ Cox-Vázquez… - Journal of Materials …, 2024 - pubs.rsc.org
Here, we report the characterization of cholesterol levels on membrane fluidity with a twisted
intramolecular charge transfer (TICT) membrane dye, namely DI-8-ANEPPS, using …

Correlation of Plasma Membrane Microviscosity and Cell Stiffness Revealed via Fluorescence-Lifetime Imaging and Atomic Force Microscopy

YM Efremov, L Shimolina, A Gulin, N Ignatova… - Cells, 2023 - mdpi.com
The biophysical properties of cells described at the level of whole cells or their membranes
have many consequences for their biological behavior. However, our understanding of the …

Understanding the Mechanism of Light-Induced Age-Related Decrease in Melanin Concentration in Retinal Pigment Epithelium Cells

AE Dontsov, MA Yakovleva, AA Vasin, AA Gulin… - International Journal of …, 2023 - mdpi.com
It is known that during the process of aging, there is a significant decrease in the number of
melanosomes in the retinal pigment epithelium (RPE) cells in the human eye. Melanosomes …

[HTML][HTML] Cholesterol metabolism in pancreatic cancer and associated therapeutic strategies

T Daya, A Breytenbach, L Gu, M Kaur - … BBA)-Molecular and Cell Biology of …, 2024 - Elsevier
Pancreatic cancer remains one of the most lethal cancers due to late diagnosis and high
chemoresistance. Despite recent progression in the development of chemotherapies …

Dysregulation of cellular membrane homeostasis as a crucial modulator of cancer risk

A Erazo‐Oliveras, M Muñoz‐Vega… - The FEBS …, 2024 - Wiley Online Library
Cellular membranes serve as an epicentre combining extracellular and cytosolic
components with membranous effectors, which together support numerous fundamental …

[HTML][HTML] The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis—A Systematic Review of Recent Literature

J Klekowski, M Chabowski… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) is among the most prevalent and lethal malignancies. Lipidomic
investigations have revealed numerous disruptions in lipid profiles across various cancers …