Harnessing anti-inflammatory pathways and macrophage nano delivery to treat inflammatory and fibrotic disorders

A Zaid, A Ariel - Advanced Drug Delivery Reviews, 2024 - Elsevier
Targeting specific organs and cell types using nanotechnology and sophisticated delivery
methods has been at the forefront of applicative biomedical sciences lately. Macrophages …

Potential effects of biomaterials on macrophage function and their signalling pathways

F Zhu, S Wang, X Zhu, C Pang, P Cui, F Yang… - Biomaterials …, 2023 - pubs.rsc.org
The use of biomaterials in biomedicine and healthcare has increased in recent years.
Macrophages are the primary immune cells that induce inflammation and tissue repair after …

Enantiomer-dependent supramolecular immunosuppressive modulation for tissue reconstruction

Z Mu, T Shen, H Deng, B Zeng, C Huang, Z Mao… - ACS …, 2024 - ACS Publications
Modulating the properties of biomaterials in terms of the host immune response is critical for
tissue repair and regeneration. However, it is unclear how the preference for the cellular …

Saikosaponin d modulates the polarization of tumor-associated macrophages by deactivating the PI3K/AKT/mTOR pathway in murine models of pancreatic cancer

X Xu, L Cui, L Zhang, L Yang, Y Zhuo, C Li - International …, 2023 - Elsevier
The tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) poses a
major obstacle to traditional and immunomodulatory cancer therapies and is closely …

Cell volume regulation modulates macrophage-related inflammatory responses via JAK/STAT signaling pathways

X Yang, Q Wang, F Shao, Z Zhuang, Y Wei, Y Zhang… - Acta Biomaterialia, 2024 - Elsevier
Cell volume as a characteristic of changes in response to external environmental cues has
been shown to control the fate of stem cells. However, its influence on macrophage behavior …

Inhibition of AXL ameliorates pulmonary fibrosis via attenuation of M2 macrophage polarization

DH Kim, K Im, IJ Baek, YJ Choi, H Lee… - European …, 2025 - publications.ersnet.org
Rationale Although a relationship between the Gas6/AXL pathway and pulmonary fibrosis
(PF) has been suggested, the precise mechanisms and clinical implications of the AXL …

Matrix‐Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility

SJ Shin, B Bayarkhangai, K Tsogtbaatar… - Advanced …, 2024 - Wiley Online Library
Macrophages encounter a myriad of biochemical and mechanical stimuli across various
tissues and pathological contexts. Notably, matrix rigidity has emerged as a pivotal regulator …

Advanced Immunomodulatory Biomaterials for Therapeutic Applications

JE Park, DH Kim - Advanced Healthcare Materials, 2024 - Wiley Online Library
The multifaceted biological defense system modulating complex immune responses against
pathogens and foreign materials plays a critical role in tissue homeostasis and disease …

Aspirin 15cH has Different Effects on Morphology and Function of Lipopolysaccharide-Challenged RAW 264.7 Macrophages In Vitro Compared to a Pharmacological …

AC von Ancken, NSS de Medeiros, SK Perdomo… - …, 2024 - thieme-connect.com
Introduction Aspirin is one of the most commonly used drugs worldwide. It is known to
present antipyretic, anti-inflammatory and anti-thrombotic actions, making it extremely useful …

[HTML][HTML] Mechanobiomaterials: Harnessing mechanobiology principles for tissue repair and regeneration

X Lin, H Yang, Y **a, K Wu, F Chu, H Zhou… - Mechanobiology in …, 2024 - Elsevier
Mechanical stimuli are known to play critical roles in mediating tissue repair and
regeneration. Recently, this knowledge has led to a paradigm shift toward proactive …