Acute graft-versus-host disease

F Malard, E Holler, BM Sandmaier, H Huang… - Nature Reviews …, 2023 - nature.com
Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of …

O Penack, M Marchetti, T Ruutu, M Aljurf… - The Lancet …, 2020 - thelancet.com
Graft-versus-host disease (GVHD) is a major factor contributing to mortality and morbidity
after allogeneic stem-cell transplantation. Because of the small number of results from well …

Post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis

J Bolaños-Meade, M Hamadani, J Wu… - … England Journal of …, 2023 - Mass Medical Soc
Background In patients undergoing allogeneic hematopoietic stem-cell transplantation
(HSCT), a calcineurin inhibitor plus methotrexate has been a standard prophylaxis against …

Sorafenib Maintenance After Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia With FLT3–Internal Tandem Duplication Mutation …

A Burchert, G Bug, LV Fritz, J Finke… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Despite undergoing allogeneic hematopoietic stem cell transplantation (HCT),
patients with acute myeloid leukemia (AML) with internal tandem duplication mutation in the …

Genome-edited, donor-derived allogeneic anti-CD19 chimeric antigen receptor T cells in paediatric and adult B-cell acute lymphoblastic leukaemia: results of two …

R Benjamin, C Graham, D Yallop, A Jozwik… - The Lancet, 2020 - thelancet.com
Background Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor
(CAR) T cells offer a novel form of CAR-T-cell product that is available for immediate clinical …

Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease

R Zeiser, N von Bubnoff, J Butler, M Mohty… - … England Journal of …, 2020 - Mass Medical Soc
Background Acute graft-versus-host disease (GVHD) remains a major limitation of
allogeneic stem-cell transplantation; not all patients have a response to standard …

Acute graft-versus-host disease—biologic process, prevention, and therapy

R Zeiser, BR Blazar - New England Journal of Medicine, 2017 - Mass Medical Soc
When T cells from a bone marrow donor begin to attack the host within 3 months after
hematopoietic-cell transplantation, acute graft-versus-host disease results. The disease …

Vedolizumab for the prevention of intestinal acute GVHD after allogeneic hematopoietic stem cell transplantation: a randomized phase 3 trial

YB Chen, M Mohty, R Zeiser, T Teshima, O Jamy… - Nature medicine, 2024 - nature.com
Acute graft-versus-host disease (aGVHD) of the lower gastrointestinal (GI) tract is a major
cause of morbidity and mortality in patients receiving allogeneic hematopoietic stem cell …

Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial

M Jagasia, MA Perales, MA Schroeder… - Blood, The Journal …, 2020 - ashpublications.org
Patients who develop steroid-refractory acute graft-versus-host disease (aGVHD) after
allogeneic hematopoietic cell transplantation have poor prognosis, highlighting an unmet …

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia …

R Benjamin, N Jain, MV Maus, N Boissel… - The Lancet …, 2022 - thelancet.com
Background The prognosis for adults with relapsed or refractory B-cell acute lymphoblastic
leukaemia remains poor. UCART19, an allogeneic genome-edited anti-CD19 chimeric …