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The neurobiology and therapeutic potential of multi-targeting β-secretase, glycogen synthase kinase 3β and acetylcholinesterase in Alzheimer's disease
Alzheimer's Disease (AD) is the most common form of dementia, affecting almost 50 million
of people around the world, characterized by a complex and age-related progressive …
of people around the world, characterized by a complex and age-related progressive …
Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …
people worldwide. In this review, AD pathology and the development of novel therapeutic …
Coumarin linked heterocyclic hybrids: a promising approach to develop multi target drugs for Alzheimer's disease
Alzheimer's disease (AD) is a major progressive and perplexing cortical degenerative
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
disease of the brain in the elderly. It contributes to a significant socioeconomic burden on …
The recent development of donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's agents: highlights from 2010 to 2020
Dementia is a term used to define different brain disorders that affect memory, thinking,
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
behavior, and emotion. Alzheimer's disease (AD) is the second cause of dementia that is …
Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update
M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - benthamdirect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …
Currently, no effective treatment is available and this is due to multiple factors involved in …
Donepezil-based central acetylcholinesterase inhibitors by means of a “bio-oxidizable” prodrug strategy: design, synthesis, and in vitro biological evaluation
L Peauger, R Azzouz, V Gembus… - Journal of medicinal …, 2017 - ACS Publications
With the aim of reducing side effects of acetylcholinesterase inhibitors (AChEIs) during
symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil …
symptomatic treatment of Alzheimer's disease, we report herein a new class of donepezil …
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid …
D Panek, A Więckowska, T Wichur, M Bajda… - European journal of …, 2017 - Elsevier
The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as
potential candidates for effective therapy. A series of phthalimide and saccharin derivatives …
potential candidates for effective therapy. A series of phthalimide and saccharin derivatives …
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological …
As currently postulated, a complex treatment may be key to an effective therapy for
Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a …
Alzheimer's disease (AD). Recent clinical trials in patients with moderate AD have shown a …
[HTML][HTML] Perspectives for new and more efficient multifunctional ligands for Alzheimer′ s disease therapy
Despite tremendous research efforts at every level, globally, there is still a lack of effective
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
drugs for the treatment of Alzheimer′ s disease (AD). The biochemical mechanisms of this …
N‐Benzyl piperidine Fragment in Drug Discovery
The N‐benzyl piperidine (N‐BP) structural motif is commonly employed in drug discovery
due to its structural flexibility and three‐dimensional nature. Medicinal chemists frequently …
due to its structural flexibility and three‐dimensional nature. Medicinal chemists frequently …