Receptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer
cell growth and metastasis. During the last two decades, several molecules targeting RTKs …

Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

1 ESGE recommends endoscopic ultrasonography (EUS) as the best tool to characterize
subepithelial lesion (SEL) features (size, location, originating layer, echogenicity, shape) …

Soft tissue sarcomas (STSs) gather over 80 histological entities, with even more molecular
subsets, characterised by a low to very low incidence in all populations. The majority of …

Background Since 2010, nationwide networks of reference centers for sarcomas
(RREPS/NETSARC/RESOS) collected and prospectively reviewed all cases of sarcomas …

Background NETSARC (netsarc. org) is a network of 26 sarcoma reference centers with
specialized multidisciplinary tumor boards (MDTB) aiming to improve the outcome of …

PURPOSE Primary or secondary mutations in KIT or platelet-derived growth factor receptor
alpha (PDGFRA) underlie tyrosine kinase inhibitor resistance in most GI stromal tumors …

Gastrointestinal stromal tumor (GIST) provides a paradigm to evaluate new molecularly
targeted therapies and to identify structural and functional mechanisms for drug response …

Anti-PD-(L) 1 therapies yield a disappointing response rate of 15% across soft-tissue
sarcomas, even if some subtypes benefit more than others. The proportions of TAMs and …

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of
the gastrointestinal tract. They are potentially malignant, and have an unpredictable …