[HTML][HTML] Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
AE Tuomisto, MJ Mäkinen… - World journal of …, 2019 - ncbi.nlm.nih.gov
Systemic inflammation is a marker of poor prognosis preoperatively present in around 20%-
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …
40% of colorectal cancer patients. The hallmarks of systemic inflammation include an …
NF-κB, inflammation, and metabolic disease
Metabolic disorders including obesity, type 2 diabetes, and atherosclerosis have been
viewed historically as lipid storage disorders brought about by overnutrition. It is now widely …
viewed historically as lipid storage disorders brought about by overnutrition. It is now widely …
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
Immune cells are somewhat unique in that activation responses can alter quantitative
phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations …
phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations …
Trade‐offs in evolutionary immunology: just what is the cost of immunity?
RL Lochmiller, C Deerenberg - Oikos, 2000 - Wiley Online Library
It has become increasingly clear that life‐history patterns among the vertebrates have been
shaped by the plethora and variety of immunological risks associated with parasitic faunas …
shaped by the plethora and variety of immunological risks associated with parasitic faunas …
Nutrient sensing and inflammation in metabolic diseases
The proper functioning of the pathways that are involved in the sensing and management of
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …
nutrients is central to metabolic homeostasis and is therefore among the most fundamental …
[HTML][HTML] The energy allocation function of sleep: a unifying theory of sleep, torpor, and continuous wakefulness
MH Schmidt - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
The energy allocation (EA) model defines behavioral strategies that optimize the temporal
utilization of energy to maximize reproductive success. This model proposes that all species …
utilization of energy to maximize reproductive success. This model proposes that all species …
Survival for immunity: the price of immune system activation for bumblebee workers
Y Moret, P Schmid-Hempel - Science, 2000 - science.org
Parasites do not always harm their hosts because the immune system keeps an infection at
bay. Ironically, the cost of using immune defenses could itself reduce host fitness. This …
bay. Ironically, the cost of using immune defenses could itself reduce host fitness. This …
Immune defense and host life history
Recent interest has focused on immune response in an evolutionary context, with particular
attention to disease resistance as a life-history trait, subject to trade-offs against other traits …
attention to disease resistance as a life-history trait, subject to trade-offs against other traits …
Immune response from a resource allocation perspective
WM Rauw - Frontiers in genetics, 2012 - frontiersin.org
The immune system is a life history trait that can be expected to trade off against other life
history traits. Whether or not a trait is considered to be a life history trait has consequences …
history traits. Whether or not a trait is considered to be a life history trait has consequences …
Variation in immune defence as a question of evolutionary ecology
P Schmid-Hempel - Proceedings of the Royal Society of …, 2003 - royalsocietypublishing.org
The evolutionary–ecology approach to studying immune defences has generated a number
of hypotheses that help to explain the observed variance in responses. Here, selected topics …
of hypotheses that help to explain the observed variance in responses. Here, selected topics …