The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …

Age-associated B cells (ABCs) are a transcriptionally and functionally unique B cell
population. In addition to arising with age and following infection, ABCs are expanded …

Age-associated B cells (ABCs) are formed under inflammatory conditions and are
considered a type of memory B cell (MBC) expressing the transcription factor T-bet. In SLE …

The age-associated B cell subset has been the focus of increasing interest over the last
decade. These cells have a unique cell surface phenotype and transcriptional signature …

CD11c+ atypical B cells (ABCs) are an alternative memory B cell lineage associated with
immunization, infection, and autoimmunity. However, the factors that drive the transcriptional …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

High-level expression of the transcription factor T-bet characterizes a phenotypically distinct
murine B cell population known as “age-associated B cells”(ABCs). T-bet–deficient mice …

Aging is considered to be an important risk factor for several inflammatory diseases. B cells
play a major role in chronic inflammatory diseases by antibody secretion, antigen …

Kidney involvement in patients with systemic lupus erythematosus—lupus nephritis (LN)—is
one of the most important and common clinical manifestations of this disease and occurs in …

Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet
promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse models, the …