Focus on mammalian thioredoxin reductases—important selenoproteins with versatile functions
ESJ Arnér - Biochimica et Biophysica Acta (BBA)-General Subjects, 2009 - Elsevier
BACKGROUND: Thioredoxin systems, involving redox active thioredoxins and thioredoxin
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
reductases, sustain a number of important thioredoxin-dependent pathways. These systems …
[HTML][HTML] Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
R Gencheva, Q Cheng, ESJ Arner - Free Radical Biology and Medicine, 2022 - Elsevier
Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …
A novel persulfide detection method reveals protein persulfide-and polysulfide-reducing functions of thioredoxin and glutathione systems
Hydrogen sulfide signaling involves persulfide formation at specific protein Cys residues.
However, overcoming current methodological challenges in persulfide detection and …
However, overcoming current methodological challenges in persulfide detection and …
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy
Cancer cells adapt to their inherently increased oxidative stress through activation of the
glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems …
glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems …
Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target
AN Kuntz, E Davioud-Charvet, AA Sayed… - PLoS …, 2007 - journals.plos.org
Background Schistosomiasis—infection with helminth parasites in the genus Schistosoma,
including S. mansoni—is a widespread, devastating tropical disease affecting more than …
including S. mansoni—is a widespread, devastating tropical disease affecting more than …
Selenocysteine in proteins—properties and biotechnological use
L Johansson, G Gafvelin, ESJ Arnér - Biochimica et Biophysica Acta (BBA) …, 2005 - Elsevier
Selenocysteine (Sec), the 21st amino acid, exists naturally in all kingdoms of life as the
defining entity of selenoproteins. Sec is a cysteine (Cys) residue analogue with a selenium …
defining entity of selenoproteins. Sec is a cysteine (Cys) residue analogue with a selenium …
Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose
Y Du, H Zhang, J Lu, A Holmgren - Journal of Biological Chemistry, 2012 - ASBMB
Thioredoxin reductase 1 (TrxR1) in cytosol is the only known reductant of oxidized
thioredoxin 1 (Trx1) in vivo so far. We and others found that aurothioglucose (ATG), a well …
thioredoxin 1 (Trx1) in vivo so far. We and others found that aurothioglucose (ATG), a well …
Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1
Q Cheng, T Sandalova, Y Lindqvist… - Journal of Biological …, 2009 - ASBMB
Selenoproteins contain a highly reactive 21st amino acid selenocysteine (Sec) encoded by
recoding of a predefined UGA codon. Because of a lack of selenoprotein supply, high …
recoding of a predefined UGA codon. Because of a lack of selenoprotein supply, high …
Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds
AB Witte, K Anestål, E Jerremalm, H Ehrsson… - Free Radical Biology …, 2005 - Elsevier
Mammalian thioredoxin reductase (TrxR) is important for cell proliferation, antioxidant
defense, and redox signaling. Together with glutathione reductase (GR) it is the main …
defense, and redox signaling. Together with glutathione reductase (GR) it is the main …
Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells
Background SecTRAPs (se lenium c ompromised t hioredoxin r eductase-derived a poptotic
p rotein s) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of …
p rotein s) can be formed from the selenoprotein thioredoxin reductase (TrxR) by targeting of …