BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

This monograph, written by the pioneers of IVF and reproductive medicine, celebrates the
history, achievements, and medical advancements made over the last 40 years in this …

Third-generation sequencing can be used in human cancer genomics and epigenomic
research. Oxford Nanopore Technologies (ONT) recently released R10. 4 flow cell, which …

Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

BACKGROUND Trophectoderm (TE) biopsy and next generation sequencing (NGS) are
currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT …

Objective To determine the pregnancy outcome potential of mosaic embryos, detected by
means of preimplantation genetic screening (PGS) with the use of next-generation …

Preimplantation genetic testing for aneuploidy (PGT-A) is widely used in IVF and aims to
improve outcomes by avoiding aneuploid embryo transfers. Chromosomal mosaicism is …

Preimplantation genetic testing for aneuploidy (PGT-A) with trophectoderm (TE) biopsy is
widely applied in in vitro fertilization (IVF) to identify aneuploid embryos. However, potential …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Mitochondria play a vital role in embryo development. They are the principal site of energy
production and have various other critical cellular functions. Despite the importance of this …