Activated fibroblasts in cancer: Perspectives and challenges
Activated fibroblasts in tumors, or cancer-associated fibroblasts (CAFs), have become a
popular research area over the past decade. As important players in many aspects of tumor …
popular research area over the past decade. As important players in many aspects of tumor …
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
The pancreatic cancer genome revisited
A Hayashi, J Hong… - … reviews Gastroenterology & …, 2021 - nature.com
Pancreatic cancer is a genetic disease, and the recurrent genetic alterations characteristic of
pancreatic cancer indicate the cellular processes that are targeted for malignant …
pancreatic cancer indicate the cellular processes that are targeted for malignant …
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
heterogeneous genetic landscape and an immunosuppressive tumor microenvironment …
Patient-specific modeling of stroma-mediated chemoresistance of pancreatic cancer using a three-dimensional organoid-fibroblast co-culture system
S Schuth, S Le Blanc, TG Krieger, J Jabs… - Journal of Experimental …, 2022 - Springer
Abstract Background Cancer-associated fibroblasts (CAFs) are considered to play a
fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and …
fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and …
[HTML][HTML] Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
(PDAC), but our understanding of their drivers, stability, and relationship to therapeutic …
Bioengineered 3D models of human pancreatic cancer recapitulate in vivo tumour biology
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
time is inadequate for clinical applications. Therefore, tailored ex vivo models that faithfully …
Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment
KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) is highly immunosuppressive and
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …
resistant to targeted and immunotherapies. Among the different PDAC subtypes, basal-like …
TNF-α-producing macrophages determine subtype identity and prognosis via AP1 enhancer reprogramming in pancreatic cancer
M Tu, L Klein, E Espinet, T Georgomanolis, F Wegwitz… - Nature cancer, 2021 - nature.com
Large-scale genomic profiling of pancreatic cancer (PDAC) has revealed two distinct
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
subtypes:'classical'and 'basal-like'. Their variable coexistence within the stromal immune …
Tissue clearing to examine tumour complexity in three dimensions
The visualization of whole organs and organisms through tissue clearing and fluorescence
volumetric imaging has revolutionized the way we look at biological samples. Its application …
volumetric imaging has revolutionized the way we look at biological samples. Its application …