Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care

N Dookie, S Rambaran, N Padayatchi… - Journal of …, 2018 - academic.oup.com
Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …

Drug Resistance Mechanisms in Mycobacterium tuberculosis

JC Palomino, A Martin - Antibiotics, 2014 - mdpi.com
Tuberculosis (TB) is a serious public health problem worldwide. Its situation is worsened by
the presence of multidrug resistant (MDR) strains of Mycobacterium tuberculosis, the …

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

PE Almeida Da Silva… - Journal of antimicrobial …, 2011 - academic.oup.com
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

[HTML][HTML] Exploring the potential of endophytes from medicinal plants as sources of antimycobacterial compounds

A Alvin, KI Miller, BA Neilan - Microbiological research, 2014 - Elsevier
Natural product drug discovery has regained interest due to low production costs, structural
diversity, and multiple uses of active compounds to treat various diseases. Attention has …

PoPMuSiC 2.1: a web server for the estimation of protein stability changes upon mutation and sequence optimality

Y Dehouck, JM Kwasigroch, D Gilis, M Rooman - BMC bioinformatics, 2011 - Springer
Background The rational design of modified proteins with controlled stability is of extreme
importance in a whole range of applications, notably in the biotechnological and …

Antibiotic resistance mechanisms in M. tuberculosis: an update

L Nguyen - Archives of toxicology, 2016 - Springer
Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015

Y Zhang, WW Yew - … Journal of Tuberculosis and Lung Disease, 2015 - ingentaconnect.com
Drug-resistant tuberculosis (DR-TB), including multi-and extensively drug-resistant TB, is
posing a significant challenge to effective treatment and TB control worldwide. New progress …

Molecular Targets Related Drug Resistance Mechanisms in MDR-, XDR-, and TDR-Mycobacterium tuberculosis Strains

HMA Hameed, MM Islam, C Chhotaray… - Frontiers in cellular …, 2018 - frontiersin.org
Tuberculosis (TB) is a formidable infectious disease that remains a major cause of death
worldwide today. Escalating application of genomic techniques has expedited the …

Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges

KA Cohen, AL Manson, CA Desjardins, T Abeel… - Genome medicine, 2019 - Springer
Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

New insights in to the intrinsic and acquired drug resistance mechanisms in mycobacteria

MJ Nasiri, M Haeili, M Ghazi, H Goudarzi… - Frontiers in …, 2017 - frontiersin.org
Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …