Clinical metagenomics

CY Chiu, SA Miller - Nature Reviews Genetics, 2019 - nature.com
Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

The potential of using blood circular RNA as liquid biopsy biomarker for human diseases

G Wen, T Zhou, W Gu - Protein & cell, 2021 - academic.oup.com
Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

Minimum redundancy maximum relevance feature selection approach for temporal gene expression data

M Radovic, M Ghalwash, N Filipovic, Z Obradovic - BMC bioinformatics, 2017 - Springer
Background Feature selection, aiming to identify a subset of features among a possibly large
set of features that are relevant for predicting a response, is an important preprocessing step …

CD177, a specific marker of neutrophil activation, is associated with coronavirus disease 2019 severity and death

Y Lévy, A Wiedemann, BP Hejblum, M Durand… - Iscience, 2021 - cell.com
The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

Robust classification of bacterial and viral infections via integrated host gene expression diagnostics

TE Sweeney, HR Wong, P Khatri - Science translational medicine, 2016 - science.org
Improved diagnostics for acute infections could decrease morbidity and mortality by
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …