Clinical metagenomic next-generation sequencing (mNGS), the comprehensive analysis of
microbial and host genetic material (DNA and RNA) in samples from patients, is rapidly …

Circular RNA (circRNA) is a novel class of single-stranded RNAs with a closed loop
structure. The majority of circRNAs are formed by a back-splicing process in pre-mRNA …

Background Feature selection, aiming to identify a subset of features among a possibly large
set of features that are relevant for predicting a response, is an important preprocessing step …

The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

Personalized medicine is a broad and rapidly advancing field of health care that is informed
by each person's unique clinical, genetic, genomic, and environmental information …

Acute respiratory infections caused by bacterial or viral pathogens are among the most
common reasons for seeking medical care. Despite improvements in pathogen-based …

Severe influenza infection has no effective treatment available. One of the key barriers to
develo** host-directed therapy is a lack of reliable prognostic factors needed to guide …

Early classification of time series has been extensively studied for minimizing class
prediction delay in time-sensitive applications such as medical diagnostic and industrial …

Vaccines to generate durable humoral immunity against antigenically evolving pathogens
such as the influenza virus must elicit antibodies that recognize conserved epitopes …

Improved diagnostics for acute infections could decrease morbidity and mortality by
increasing early antibiotics for patients with bacterial infections and reducing unnecessary …