Recent progress in the science of complex coacervation

CE Sing, SL Perry - Soft Matter, 2020 - pubs.rsc.org
Complex coacervation is an associative, liquid–liquid phase separation that can occur in
solutions of oppositely-charged macromolecular species, such as proteins, polymers, and …

Complex coacervate‐based materials for biomedicine

WC Blocher, SL Perry - Wiley Interdisciplinary Reviews …, 2017 - Wiley Online Library
There has been increasing interest in complex coacervates for deriving and transporting
biomaterials. Complex coacervates are a dense, polyelectrolyte‐rich liquid that results from …

Development of the modern theory of polymeric complex coacervation

CE Sing - Advances in colloid and interface science, 2017 - Elsevier
Oppositely charged polymers can undergo the process of complex coacervation, which
refers to a liquid–liquid phase separation driven by electrostatic attraction. These materials …

Protein encapsulation via polypeptide complex coacervation

KA Black, D Priftis, SL Perry, J Yip, WY Byun… - ACS Macro …, 2014 - ACS Publications
Proteins have gained increasing success as therapeutic agents; however, challenges exist
in effective and efficient delivery. In this work, we present a simple and versatile method for …

Formation of multiphase complex coacervates and partitioning of biomolecules within them

GA Mountain, CD Keating - Biomacromolecules, 2019 - ACS Publications
Biological systems employ liquid–liquid phase separation to localize macromolecules and
processes. The properties of intracellular condensates that allow for multiple, distinct liquid …

Chirality-selected phase behaviour in ionic polypeptide complexes

SL Perry, L Leon, KQ Hoffmann, MJ Kade… - Nature …, 2015 - nature.com
Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors
determining whether the phase of the complex is solid or liquid remain unclear. Ionic …

The effect of salt on the complex coacervation of vinyl polyelectrolytes

SL Perry, Y Li, D Priftis, L Leon, M Tirrell - Polymers, 2014 - mdpi.com
Complex coacervation is an electrostatically-driven phase separation phenomenon that is
utilized in a wide range of everyday applications and is of great interest for the creation of …

Protein encapsulation using complex coacervates: what nature has to teach us

WC Blocher McTigue, SL Perry - Small, 2020 - Wiley Online Library
Protein encapsulation is a growing area of interest, particularly in the fields of food science
and medicine. The sequestration of protein cargoes is achieved using a variety of methods …

Designing electrostatic interactions via polyelectrolyte monomer sequence

TK Lytle, LW Chang, N Markiewicz, SL Perry… - ACS central …, 2019 - ACS Publications
Charged polymers are ubiquitous in biological systems because electrostatic interactions
can drive complicated structure formation and respond to environmental parameters such as …

Prebiotically-relevant low polyion multivalency can improve functionality of membraneless compartments

FP Cakmak, S Choi, MCO Meyer… - Nature …, 2020 - nature.com
Multivalent polyions can undergo complex coacervation, producing membraneless
compartments that accumulate ribozymes and enhance catalysis, and offering a mechanism …