Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …

Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Diabetic neuropathy (DN) is one of the main microvascular complications of both type 1 and
type 2 diabetes mellitus. Sometimes, this could already be present at the time of diagnosis …

Objective The serum lipidomic profile associated with neuropathy in type 2 diabetes is not
well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting …

Schwann cells (SCs) support peripheral nerves under homeostatic conditions, independent
of myelination, and contribute to damage in prediabetic peripheral neuropathy (PN). Here …

Hyperlipidaemia, particularly hypertriglyceridemia, is associated with the development and
progression of neuropathy. Lipid modifying agents may represent a potential therapeutic …

Context Peripheral neuropathy (PN) is a frequent prediabetes and type 2 diabetes (T2D)
complication. Multiple clinical studies reveal that obesity and dyslipidemia can also drive PN …

Abstract Purpose of Review Metabolomics enables rapid interrogation of widespread
metabolic processes making it well suited for studying diabetes. Here, we review the current …

As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase
worldwide, accompanying complications are also on the rise. The most prevalent …

Diabetes mellitus (DM) is a severe chronic diseases with a global prevalence of 9%, leading
to poor health and high health care costs, and is a direct cause of millions of deaths each …