The persistence of pathological memory is the basis of several psychiatric disorders.
Memory retrieval induces “reconsolidation”, a time interval during which the original memory …

Fear is an adaptive emotion that mobilizes defensive resources upon confrontation with
danger. However, fear becomes maladaptive and can give rise to the development of …

It has been proposed that memory retrieval can destabilize consolidated memories, after
which they need to be reconsolidated in order to be retained. The presentation of relevant …

Reactivation of consolidated memories can induce a labile period, in which these
reactivated memories might be susceptible to change and need reconsolidation. Prediction …

Experimental evidence suggests that the return of fear may be prevented by post-retrieval
extinction (PRE), a procedure consisting of extinction training after the presentation of a …

Background Over a decade and a half of research has resulted in inconsistent evidence for
the efficacy of d-cycloserine (DCS), a partial glutamatergic N-methyl-D-aspartate agonist, for …

Persistent and maladaptive drug-related memories represent a key component in drug
addiction. Converging evidence from both preclinical and clinical studies has demonstrated …

Fear memories can be updated behaviorally by delivering extinction trials during the
reconsolidation window, which results in a persistent attenuation of fear memories (Monfils …

Although exposure-based therapy is widely recognized as effective for treating various
anxiety disorders, a significant proportion of patients fail to benefit or experience a return of …

Here, we describe the efforts we dedicated to the challenge of modifying entrenched
emotionally laden memories. In recent years, through a number of collaborations and using …