Host response mechanisms in periodontal diseases

N Silva, L Abusleme, D Bravo, N Dutzan… - Journal of Applied Oral …, 2015 - SciELO Brasil
Periodontal diseases usually refer to common inflammatory disorders known as gingivitis
and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm …

Destructive and protective roles of cytokines in periodontitis: a re-appraisal from host defense and tissue destruction viewpoints

GP Garlet - Journal of dental research, 2010 - journals.sagepub.com
Periodontal diseases (PD) are chronic infectious inflammatory diseases characterized by the
destruction of tooth-supporting structures, being the presence of periodontopathogens …

Periodontal disease: linking the primary inflammation to bone loss

A Di Benedetto, I Gigante, S Colucci… - Journal of Immunology …, 2013 - Wiley Online Library
Periodontal disease (PD), or periodontitis, is defined as a bacterially induced disease of the
tooth‐supporting (periodontal) tissues. It is characterized by inflammation and bone loss; …

How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?

PM Preshaw, JJ Taylor - Journal of clinical periodontology, 2011 - Wiley Online Library
Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving
immune responses impacted our understanding of periodontitis? J Clin Periodontol 2011; …

Inflammation and bone loss in periodontal disease

DL Cochran - Journal of periodontology, 2008 - Wiley Online Library
Inflammation and bone loss are hallmarks of periodontal disease (PD). The question is how
the former leads to the latter. Accumulated evidence demonstrates that PD involves …

Review of osteoimmunology and the host response in endodontic and periodontal lesions

DT Graves, T Oates, GP Garlet - Journal of oral microbiology, 2011 - Taylor & Francis
Both lesions of endodontic origin and periodontal diseases involve the host response to
bacteria and the formation of osteolytic lesions. Important for both is the upregulation of …

Inflammation and uncoupling as mechanisms of periodontal bone loss

DT Graves, J Li, DL Cochran - Journal of dental research, 2011 - journals.sagepub.com
Periodontal disease is characterized by both inflammation and bone loss. Advances in
research in both these areas have led to a new appreciation of not only each field but also …

The use of rodent models to investigate host–bacteria interactions related to periodontal diseases

DT Graves, D Fine, YTA Teng… - Journal of clinical …, 2008 - Wiley Online Library
Even though animal models have limitations, they are often superior to in vitro or clinical
studies in addressing mechanistic questions and serve as an essential link between …

Chemokines in oral inflammatory diseases: apical periodontitis and periodontal disease

TA Silva, GP Garlet, SY Fukada… - Journal of dental …, 2007 - journals.sagepub.com
The inflammatory oral diseases are characterized by the persistent migration of
polymorphonuclear leukocytes, monocytes, lymphocytes, plasma and mast cells, and …

Molecular basis for immunohistochemical and inflammatory changes during progression of gingivitis to periodontitis

S Kurgan, A Kantarci - Periodontology 2000, 2018 - Wiley Online Library
Two common diseases–gingivitis and periodontitis–affect the periodontium. Symptoms of
disease entities are used for distinguishing various forms of gingivitis and periodontitis …