Background: A wide class of human diseases and neurodegenerative disorders, such as
Alzheimer's disease, is due to the failure of a specific peptide or protein to keep its native …

Protein aggregation phenomenon is closely related to the formation of amyloids which
results in many neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's, and …

Hen egg white lysozyme (HEWL) is widely used as a model protein for amyloid research. In
this study, we aim to use Fourier transform infrared (FTIR) spectroscopy to gain new …

AIM: The current work is aimed at understanding the effect of pH on the thermal stability of
hen egg white lysozyme (HEWL) at high concentration (200 mg/mL). MATERIALS AND …

The pharmaceutical industry uses surface-active agents (excipients) in protein drug
formulations to prevent the aggregation, denaturation, and unwanted immunological …

Surface protection against biofilms is still an open challenge. Current strategies rely on
coatings that are meant to guarantee antiadhesive or antimicrobial effects. While it seems …

Solvents that support protein functionality are important for biochemical applications, and
new solvents are required. Here we employ FTIR and fluorescence spectroscopies, small …

Studies of protein unfolding mechanisms are critical for understanding protein functions
inside cells, de novo protein design as well as defining the role of protein misfolding in …

Materials based on ordered protein aggregates have recently received a lot of attention for
their application as drug carriers, due to their biocompatibility and their ability to sequester …

We studied the effects of temperature and hydrostatic pressure on the dynamical properties
and folding stability of highly concentrated lysozyme solutions in the absence and presence …