Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP)
receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas …

Prevention of Opioid Overdose This review explains harm-reduction strategies for three
groups of patients: those who have not received previous opioid therapy, those receiving …

Objective The purpose of this study is to examine the extent to which numeric rating scale
(NRS) scores collected during usual care are associated with more robust and validated …

The multitude of treatments available for tens of millions of US adults with moderate/severe
chronic pain have limited efficacy. Long-term opioid therapy (LTOT) is a widely available …

Opinion statement Long-term opioid therapy (LTOT) for chronic cancer and non-cancer pain
is commonly ineffective in providing its stated goal of improving function through good …

The increase in opioid prescriptions in the United States has been accompanied by an
increase in misuse as well as overdose and toxicity related morbidity and mortality …

Mindfulness-, compassion-, and acceptance-based (ie,“third wave”) psychotherapies are
effective for treating chronic pain conditions. Many of these programs require that patients …

Background Many clinicians are reevaluating the use of long-term opioid therapy (LTOT) for
chronic pain in response to the opioid crisis and calls from organizations including the …

Buprenorphine, a novel opioid with complex pharmacology, is effective for treating pain and
is qualitatively safer than high‐dose full agonist opioid therapy; but transitioning to …

Tapering opioids for chronic pain can be challenging for both patients and prescribers, both
of whom may be unsure of what to expect in terms of pain, distress, activity interference, and …