The heterogeneity of mesenchymal stem cells: an important issue to be addressed in cell therapy

J Li, Z Wu, L Zhao, Y Liu, Y Su, X Gong, F Liu… - Stem cell research & …, 2023 - Springer
With the continuous improvement of human technology, the medical field has gradually
moved from molecular therapy to cellular therapy. As a safe and effective therapeutic tool …

[HTML][HTML] Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

[HTML][HTML] Extracellular vesicles in skin wound healing

D Narauskaitė, G Vydmantaitė, J Rusteikaitė… - Pharmaceuticals, 2021 - mdpi.com
Each year, millions of individuals suffer from a non-healing wound, abnormal scarring, or
injuries accompanied by an infection. For these cases, scientists are searching for new …

Mesenchymal stem cells from adipose tissue in clinical applications for dermatological indications and skin aging

M Gaur, M Dobke, VV Lunyak - International journal of molecular sciences, 2017 - mdpi.com
Operating at multiple levels of control, mesenchymal stem cells from adipose tissue (ADSCs)
communicate with organ systems to adjust immune response, provide signals for …

Adipose mesenchymal stem cell–derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances

M Cao, Y Zhao, T Chen, Z Zhao, B Zhang, C Yuan… - Biomaterials, 2022 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in
women of childbearing age. Adipose mesenchymal stem cells (AMSCs) secrete cytokines …

Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

BC Lee, KS Kang - Stem cell research & therapy, 2020 - Springer
Mesenchymal stem cells (MSCs) have recently been considered a promising alternative
treatment for diverse immune disorders due to their unique biomedical potentials including …

Mesenchymal stem cells secretory responses: senescence messaging secretome and immunomodulation perspective

VV Lunyak, A Amaro-Ortiz, M Gaur - Frontiers in Genetics, 2017 - frontiersin.org
Mesenchymal stem/stromal cells (MSC) have been tested in a significant number of clinical
trials, where they exhibit regenerative and repair properties directly through their …

Role of adipose-derived mesenchymal stem cells in bone regeneration

CS Lau, SY Park, LP Ethiraj, P Singh, G Raj… - International Journal of …, 2024 - mdpi.com
Bone regeneration involves multiple factors such as tissue interactions, an inflammatory
response, and vessel formation. In the event of diseases, old age, lifestyle, or trauma, bone …

[HTML][HTML] Characteristics and regulation of mesenchymal stem cell plasticity by the microenvironment—Specific factors involved in the regulation of MSC plasticity

L Tan, X Liu, H Dou, Y Hou - Genes & diseases, 2022 - Elsevier
Mesenchymal stem cells (MSCs), multipotent stromal cells, have attracted extensive
attention in the field of regenerative medicine and cell therapy due to the capacity of self …

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

Y Lu, CTY Tan, MSZ Nyunt, EWH Mok, X Camous… - …, 2016 - pmc.ncbi.nlm.nih.gov
Chronic systematic inflammation and reduced immune system fitness are considered
potential contributing factors to the development of age-related frailty, but the underlying …