Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Successful genome duplication is required for cell proliferation and demands extraordinary
precision and accuracy. The mechanisms by which cells enter, progress through, and exit S …

The eukaryotic mini-chromosome maintenance (MCM) complex, composed of MCM proteins
2–7, is the core component of the replisome that acts as the DNA replicative helicase to …

Accurate and integral cellular DNA replication is modulated by multiple replication‐
associated proteins, which is fundamental to preserve genome stability. Furthermore …

Genome amplification (DNA synthesis) is one of the most demanding cellular processes in
all proliferative cells. The DNA replication machinery (also known as the replisome) …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder that is caused by a
point mutation in the LMNA gene, resulting in production of a truncated farnesylated …

Topoisomerase IIα (Topo IIα), a well-conserved double-stranded DNA (dsDNA)-specific
decatenase, processes dsDNA catenanes resulting from DNA replication during mitosis …

Biochemical and cryo‐electron microscopy studies have just been published revealing
interactions among proteins of the yeast replisome that are important for highly coordinated …

DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging
for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands …