The Central Nervous System (CNS) is vulnerable to a range of diseases, including
neurodegenerative and oncological conditions, which present significant treatment …

Human induced pluripotent stem cells (hiPSCs) offer opportunities to study human biology
where primary cell types are limited. CRISPR technology allows forward genetic screens …

Gene replacement therapies primarily rely on adeno-associated virus (AAV) vectors for
transgene expression. However, episomal expression can decline over time due to vector …

Transgene silencing provides a significant challenge in animal model production via gene
engineering using viral vectors or transposons. Selecting an appropriate strategy, contingent …

The SARS-CoV-2 pandemic has underscored the necessity for functional transgenic animal
models for testing. Mouse lines with overexpression of the human receptor ACE2 serve as …

Tools developed in the fields of genome engineering, precise gene regulation, and synthetic
gene networks have an increasing number of applications. When shared with the scientific …

In humans and other mammals, injury to the central nervous system (CNS) can cause a
permanent loss of neuronal function, leading to cognitive defects, limb paralysis, and other …

Dynamic interactions between transcription factors govern changes in gene expression that
mediate changes in cell state accompanying injury response and regeneration …

Arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome is an inherited disorder
typically arising from mutations in the vacuolar protein sorting 33 homolog B (VPS33B) …

Paediatric brain tumours are the leading cause of cancer related death in children.
Ependymomas are the third most common brain tumour in children. These tumours are …