Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …

ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Effective treatment of metastatic cancers usually requires the use of toxic chemotherapy. In
most cases, multiple drugs are used, as resistance to single agents occurs almost …

The development of multidrug resistance (MDR) to chemotherapy remains a major
challenge in the treatment of cancer. Resistance exists against every effective anticancer …

Paclitaxel (Taxol®) is a member of the taxane class of anticancer drugs and one of the most
common chemotherapeutic agents used against many forms of cancer. Paclitaxel is a …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

The taxanes, paclitaxel and docetaxel are microtubule-stabilizing agents that function
primarily by interfering with spindle microtubule dynamics causing cell cycle arrest and …