Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

The potential for animal models to provide insight into mild traumatic brain injury: translational challenges and strategies

SR Shultz, SJ McDonald, CV Haar, A Meconi… - Neuroscience & …, 2017 - Elsevier
Mild traumatic brain injury (mTBI) is a common health problem. There is tremendous
variability and heterogeneity in human mTBI, including mechanisms of injury, biomechanical …

Craniotomy: true sham for traumatic brain injury, or a sham of a sham?

JT Cole, A Yarnell, WS Kean, E Gold, B Lewis… - Journal of …, 2011 - liebertpub.com
Neurological dysfunction after traumatic brain injury (TBI) is caused by both the primary
injury and a secondary cascade of biochemical and metabolic events. Since TBI can be …

Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats

PK Dash, SA Orsi, M Zhang, RJ Grill, S Pati, J Zhao… - PloS one, 2010 - journals.plos.org
Background Traumatic brain injury (TBI) initiates a complex series of neurochemical and
signaling changes that lead to pathological events including neuronal hyperactivity …

[HTML][HTML] Treating traumatic brain injury with minocycline

PJ Bergold, R Furhang, S Lawless - Neurotherapeutics, 2023 - Elsevier
Traumatic brain injury (TBI) results in both rapid and delayed brain damage. The speed,
complexity, and persistence of TBI present large obstacles to drug development. Preclinical …

Systematic Review of Human and Animal Studies Examining the Efficacy and Safety of N-Acetylcysteine (NAC) and N-Acetylcysteine Amide (NACA) in Traumatic …

J Bhatti, B Nascimento, U Akhtar, SG Rhind… - Frontiers in …, 2018 - frontiersin.org
Background No new therapies for traumatic brain injury (TBI) have been officially translated
into current practice. At the tissue and cellular level, both inflammatory and oxidative …

Minocycline plus N-acetylcysteine synergize to modulate inflammation and prevent cognitive and memory deficits in a rat model of mild traumatic brain injury

M Haber, SGA Baki, NM Grin'kina, R Irizarry… - Experimental …, 2013 - Elsevier
Traumatic brain injury (TBI) differs in severity from severe to mild. This study examined
whether a combination of the drugs minocycline (MINO) plus N-acetylcysteine (NAC) …

Behavioral and histopathological alterations resulting from mild fluid percussion injury

MJ Hylin, SA Orsi, J Zhao, K Bockhorst… - Journal of …, 2013 - liebertpub.com
The majority of people who sustain a traumatic brain injury (TBI) have an injury that can be
classified as mild (often referred to as concussion). Although head CT scans for most …

Minocycline synergizes with N-acetylcysteine and improves cognition and memory following traumatic brain injury in rats

SG Abdel Baki, B Schwab, M Haber, AA Fenton… - PloS one, 2010 - journals.plos.org
Background There are no drugs presently available to treat traumatic brain injury (TBI). A
variety of single drugs have failed clinical trials suggesting a role for drug combinations …

Head rotational acceleration characteristics influence behavioral and diffusion tensor imaging outcomes following concussion

BD Stemper, AS Shah, FA Pintar, M McCrea… - Annals of biomedical …, 2015 - Springer
A majority of traumatic brain injuries (TBI) in motor vehicle crashes and sporting
environments are mild and caused by high-rate acceleration of the head. For injuries caused …