Immunity to fungi in the lung
LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Two sides of the same coin: Protective versus pathogenic CD4+ resident memory T cells
AE Oja, RAW van Lier, P Hombrink - Science immunology, 2022 - science.org
The ability of the adaptive immune system to form memory is key to providing protection
against secondary infections. Resident memory T cells (TRM) are specialized T cell …
against secondary infections. Resident memory T cells (TRM) are specialized T cell …
T cell responses to control fungal infection in an immunological memory lens
In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …
Vaccines to prevent coccidioidomycosis: a gene-deletion mutant of Coccidioides posadasii as a viable candidate for human trials
Coccidioidomycosis is an endemic fungal infection that is reported in up to 20,000 persons
per year and has an economic impact close to $1.5 billion. Natural infection virtually always …
per year and has an economic impact close to $1.5 billion. Natural infection virtually always …
Vaccination with O-linked Mannans Protects against Systemic Candidiasis through Innate Lymphocyte Populations
Candida spp. are the fourth leading cause of bloodstream infections in hospitalized patients
and the most common cause of invasive fungal infection. No vaccine against Candida spp …
and the most common cause of invasive fungal infection. No vaccine against Candida spp …
Immunity to fungi and vaccine considerations
Fungal disease poses a growing threat to public health that our current antifungal therapies
are not well equipped to meet. As the population of immunocompromised hosts expands …
are not well equipped to meet. As the population of immunocompromised hosts expands …
Efficient enzyme-free method to assess the development and maturation of the innate and adaptive immune systems in the mouse colon
Researchers who aim to globally analyze the gastrointestinal immune system via flow
cytometry have many protocol options to choose from, with specifics generally tied to gut …
cytometry have many protocol options to choose from, with specifics generally tied to gut …
Tissue-resident memory T cells in antifungal immunity
S LeibundGut-Landmann - Frontiers in immunology, 2021 - frontiersin.org
Fungi are an integral part of the mammalian microbiota colonizing most if not all mucosal
surfaces and the skin. Maintaining stable colonization on these surfaces is critical for …
surfaces and the skin. Maintaining stable colonization on these surfaces is critical for …
Combination adjuvants enhance recombinant protein vaccine protection against fungal infection
The development of effective vaccines against fungal infections requires the induction of
protective, pathogen-specific cell-mediated immune responses. Here, we asked whether …
protective, pathogen-specific cell-mediated immune responses. Here, we asked whether …
Distinctive populations of CD4+ T cells associated with vaccine efficacy
Memory T cells underpin vaccine-induced immunity but are not yet fully understood. To
distinguish features of memory cells that confer protective immunity, we used single cell …
distinguish features of memory cells that confer protective immunity, we used single cell …