Background One of the criteria to objectively prioritize merozoite antigens for malaria
vaccine development is the demonstration that naturally acquired antibodies are associated …

With malaria elimination back on the international agenda, programs face the challenge of
targeting all Plasmodium infections, not only symptomatic cases. As asymptomatic …

Background An understanding of the mechanisms mediating protective immunity against
malaria in humans is currently lacking, but critically important to advance the development of …

Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and
communities are needed to guide and evaluate malaria control interventions. Serologic …

Background. Variation in the risk of malaria within populations is a frequently described but
poorly understood phenomenon. This heterogeneity creates opportunities for targeted …

BACKGROUND The use of high-throughput technologies has enabled rapid advancement
in the knowledge of host immune responses to pathogens. Our objective was to compare the …

Vaccination with the pre-erythrocytic malaria vaccine RTS, S induces high levels of
antibodies and CD4+ T cells specific for the circumsporozoite protein (CSP). Using a …

Exposure to Plasmodium falciparum is associated with circulating “atypical” memory B cells
(atMBCs), which appear similar to dysfunctional B cells found in HIV-infected individuals …

Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection, but
specific interactions involved in cerebral homing of infected erythrocytes (IEs) are poorly …

Previous analyses have suggested that immunity to non-cerebral severe malaria due to
Plasmodium falciparum is acquired after only a few infections, whereas longitudinal studies …