Mitochondria as a cellular hub in infection and inflammation

P Andrieux, C Chevillard, E Cunha-Neto… - International journal of …, 2021 - mdpi.com
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Pharmacological activities, therapeutic effects, and mechanistic actions of trigonelline

V Nguyen, EG Taine, D Meng, T Cui, W Tan - International journal of …, 2024 - mdpi.com
Trigonelline (TRG) is a natural polar hydrophilic alkaloid that is found in many plants such as
green coffee beans and fenugreek seeds. TRG potentially acts on multiple molecular …

ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer

S Dong, S Liang, Z Cheng, X Zhang, L Luo, L Li… - Journal of Experimental …, 2022 - Springer
Background Acquired resistance of 5-fluorouracil (5-FU) remains a clinical challenge in
colorectal cancer (CRC), and efforts to develop targeted agents to reduce resistance have …

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway

F Chen, C Chu, X Wang, C Yang, Y Deng, Z Duan… - Food & function, 2023 - pubs.rsc.org
Background: Hesperetin (HES), one of the major flavonoids that has various biological
activities, such as anti-inflammatory and antioxidant activities, may preserve the intestinal …

Mitochondrial and metabolic dysfunction of peripheral immune cells in multiple sclerosis

PF Wang, F Jiang, QM Zeng, WF Yin, YZ Hu… - Journal of …, 2024 - Springer
Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by the infiltration of
inflammatory cells and demyelination of nerves. Mitochondrial dysfunction has been …

Epstein-Barr virus: the mastermind of immune chaos

JM Silva, CEC Alves, GS Pontes - Frontiers in Immunology, 2024 - frontiersin.org
The Epstein-Barr virus (EBV) is a ubiquitous human pathogen linked to various diseases,
including infectious mononucleosis and multiple types of cancer. To control and eliminate …

Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells

T Wang, X Wu, Y Song, H Cheng - Journal of Cancer, 2020 - pmc.ncbi.nlm.nih.gov
Our study explored the tumor-suppressive effect of curcumin on cervical cancer cells.
Cervical cancer is one of the most common cancers among women worldwide. Acquired …

SHED-derived exosomes promote LPS-induced wound healing with less itching by stimulating macrophage autophagy

Y **e, L Yu, Z Cheng, Y Peng, Z Cao, B Chen… - Journal of …, 2022 - Springer
High-quality cutaneous wound healing is associated with rapid wound closure and a
comfortable healing process. Currently, exosomes derived from mesenchymal stem cells …

Glucomannan from Aloe vera gel maintains intestinal barrier integrity via mitigating anoikis mediated by Nrf2-mitochondria axis

D Zhang, X Zhou, K Zhang, Y Yu, SW Cui… - International journal of …, 2023 - Elsevier
Impairment of intestinal epithelium barrier is a hallmark of gut pathology. Cell death can
compromise barrier function and impair epithelial restitution directly or indirectly in …

[HTML][HTML] New insights into curcumin-and resveratrol-mediated anti-cancer effects

A Arena, MA Romeo, R Benedetti, L Masuelli, R Bei… - Pharmaceuticals, 2021 - mdpi.com
Curcumin and resveratrol are bioactive natural compounds displaying anti-inflammatory,
anti-oxidant and anti-cancer properties. In this study, we compared the cytotoxic effects of …