Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

Objectives Neuropathological studies have shown that multiple sclerosis (MS) lesions are
heterogeneous in terms of myelin/axon damage and repair as well as iron content. However …

Obtaining a histological fingerprint from the in-vivo brain has been a long-standing target of
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …

We present the first three-dimensional (3D) concordance maps of cyto-and fiber architecture
of the human brain, combining histology, immunohistochemistry, and 7-T quantitative …

Abstract Development of myelin, a fatty sheath that insulates nerve fibers, is critical for brain
function. Myelination during infancy has been studied with histology, but postmortem data …

Myelin loss and iron accumulation are cardinal features of aging and various
neurodegenerative diseases. Oligodendrocytes incorporate iron as a metabolic substrate for …

For over a century, researchers have examined the functional relevancy of white matter
bundles. Consequently, many large-scale bundles spanning several centimeters have been …

Strict iron regulation is essential for normal brain function. The iron homeostasis, determined
by the milieu of available iron compounds, is impaired in aging, neurodegenerative …

Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's
disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal …

Object This study evaluates inter-site and intra-site reproducibility at ten different 7 T sites for
quantitative brain imaging. Material and Methods Two subjects–termed the “traveling heads” …