Conclusions In a large Western cohort of patients with HCC, we found heterogeneous tumor
growth patterns, with one‐fourth exhibiting rapid growth and over one‐third having indolent …

Objective Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative
stress and mitochondrial dysfunction, which can be eluded by the co-administration of the …

Polystyrene nanoparticles (PS‐NPs) as an issue of global environmental concern, have
been shown to induce hepatic toxicity via triggering oxidative injury and inflammation. Non …

The zonation of liver metabolic processes is well-characterized; however, little is known
about the cell type-specificity and zonation of sexually dimorphic gene expression or its …

Aims Diets containing high‐fat and high sugar (HFHS) lead to overweight/obesity.
Overweight/obesity increases the risk of infertility, and of the pregnant mother and her child …

Background Many chronic metabolic diseases, such as obesity and type 2 diabetes (T2DM),
are closely related to a chronic low-grade inflammatory state in tissues. The high prevalence …

Purpose: High prevalence of nonalcoholic fatty liver disease (NAFLD) among patients with
type 2 diabetes has implicated the role of hepatic insulin resistance (IR) in the diseases. To …

Background and Aims The augmenter of liver regeneration (ALR) protein is critical for lipid
homeostasis and mitochondrial function. We investigated high‐fat/high‐carbohydrate …

Non-alcoholic fatty liver disease (NAFLD) is a range of disorders characterized by lipid
accumulation in hepatocytes. Although this spectrum of disorders is associated with adult …

Background: Obesity during pregnancy is related to adverse maternal and neonatal
outcomes. Factors involved in these outcomes may include increased maternal insulin …