This study presents a broad perspective of hybrid process modeling combining the scientific
knowledge and data analytics in bioprocessing and chemical engineering with a science …

Continuous biopharmaceutical manufacturing is currently a field of intense research due to
its potential to make the entire production process more optimal for the modern, ever …

The main objectives of bioprocesses are to reliably deliver drugs in a relatively short time
frame with high quality within a tight regulatory framework. Bioprocesses are highly complex …

The bioprocessing industry is undergoing a significant transformation in its approach to
quality assurance, shifting from the traditional Quality by Testing (QbT) to Quality by Design …

Background In research and production, reproducibility is a key factor, to meet high quality
and safety standards and maintain productivity. For microbial fermentations, complex …

The development and adoption of digital twins (DT) for Quality-by-Design (QbD)-based
processes with flexible operating points within a proven acceptable range (PAR) and …

The pharmaceutical industry's shift towards biological therapeutics has led to a transition
from conventional batch production to continuous manufacturing. This change highlights the …

This study focuses on the production phase of drug development and examines approaches
and their progress indicators for enhancing the quality of pharmaceutical products and …

The capabilities of digital twins (DT) and the successes they have demonstrated in various
industries have attracted significant attention from the biopharmaceutical manufacturing …

The biopharmaceutical industry is transitioning toward the adoption of continuous
biomanufacturing practices that are often more flexible and efficient than traditional batch …