Cancer cell states: Lessons from ten years of single-cell RNA-sequencing of human tumors
Human tumors are intricate ecosystems composed of diverse genetic clones and malignant
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …
cell states that evolve in a complex tumor micro-environment. Single-cell RNA-sequencing …
PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity
Adenocarcinomas from multiple tissues can converge to treatment-resistant small cell
neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 …
neuroendocrine (SCN) cancers composed of ASCL1, POU2F3, NEUROD1, and YAP1 …
[HTML][HTML] Therapeutic Exploitation of Neuroendocrine Transdifferentiation Drivers in Prostate Cancer
Neuroendocrine prostate cancer (NEPC), an aggressive and lethal subtype of prostate
cancer (PCa), often arises as a resistance mechanism in patients undergoing hormone …
cancer (PCa), often arises as a resistance mechanism in patients undergoing hormone …
Time to Castration Resistance is Associated With Overall Survival Even After the Achievement of Castration Resistance in Metastatic Prostate Cancer
H Kato, Y Goto, S Kojima, Y Onoda, K Wakai… - The …, 2025 - Wiley Online Library
Background Recent clinical trials have shown that patients with metastatic castration‐
sensitive prostate cancer in real‐world settings have different overall survival (OS) rates after …
sensitive prostate cancer in real‐world settings have different overall survival (OS) rates after …
Basal cell of origin resolves neuroendocrine-tuft lineage plasticity in cancer
AS Ireland, SB Hawgood, DA **e, MW Barbier… - bioRxiv, 2024 - biorxiv.org
Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by
expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine …
expression of ASCL1 and POU2F3 transcription factors, respectively. Neuroendocrine …
Systematic Benchmarking of High-Throughput Subcellular Spatial Transcriptomics Platforms
P Ren, R Zhang, Y Wang, P Zhang, C Luo, S Wang… - bioRxiv, 2024 - biorxiv.org
Recent advancements in spatial transcriptomics technologies have significantly enhanced
resolution and throughput, underscoring an urgent need for systematic benchmarking. To …
resolution and throughput, underscoring an urgent need for systematic benchmarking. To …