Prevention of neurodegenerative diseases is presently a major goal for our Society and
melatonin, an unusual phylogenetically conserved molecule present in all aerobic …

Traumatic brain injury (TBI) is one of the most prevalent causes of permanent physical and
cognitive disabilities. TBI pathology results from primary insults and a multi‐mechanistic …

Down syndrome (DS) is a genetic disorder caused by the presence of a third copy of
chromosome 21. DS affects multiple organs, but it invariably results in altered brain …

People with autism spectrum disorder (ASD) commonly experience other comorbidities.
Studies indicate that between 50% and 83% of individuals with ASD have sleep problems or …

This article discusses the role that melatonin may have in the prevention and treatment of
Parkinson's disease (PD). In parkinsonian patients circulating melatonin levels are …

Melatonin, a neurohormone secreted by the pineal gland and regulated by the
suprachiasmatic nucleus (SCN) of the hypothalamus, is synthesized and directly released …

Drug addiction is a chronic brain disease that is a serious social problem and causes
enormous financial burden. Because mitochondrial abnormalities have been associated …

The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …

Background Microdeletion of the human chromosomal region 16p11. 2 (16p11. 2+/-) is a
prevalent genetic factor associated with autism spectrum disorder (ASD) and other …

Agomelatine, a melatonergic antidepressant with a rapid onset of action, is one of the most
recent drugs in the antidepressant category. Agomelatine's antidepressant actions are …