Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Advancing the understanding of autism disease mechanisms through genetics

L de la Torre-Ubieta, H Won, JL Stein… - Nature medicine, 2016 - nature.com
Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Inhibition in the amygdala anxiety circuitry

O Babaev, C Piletti Chatain… - Experimental & molecular …, 2018 - nature.com
Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the
anxiolytic effect of the benzodiazepine class of γ-aminobutyric acid (GABA) receptor …

Reconsidering animal models used to study autism spectrum disorder: Current state and optimizing future

JL Silverman, A Thurm, SB Ethridge… - Genes, brain and …, 2022 - Wiley Online Library
Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and
intellectual disability (ID), are pervasive, often lifelong disorders, lacking evidence‐based …

Prefrontal cortex and social cognition in mouse and man

LK Bicks, H Koike, S Akbarian, H Morishita - Frontiers in psychology, 2015 - frontiersin.org
Social cognition is a complex process that requires the integration of a wide variety of
behaviors, including salience, reward-seeking, motivation, knowledge of self and others …

A standardized social preference protocol for measuring social deficits in mouse models of autism

B Rein, K Ma, Z Yan - Nature protocols, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

Interneuron dysfunction in psychiatric disorders

O Marín - Nature Reviews Neuroscience, 2012 - nature.com
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …

Animal models of neuropsychiatric disorders

EJ Nestler, SE Hyman - Nature neuroscience, 2010 - nature.com
Modeling of human neuropsychiatric disorders in animals is extremely challenging given the
subjective nature of many symptoms, the lack of biomarkers and objective diagnostic tests …