The extracellular matrix (ECM) of blood vessels, which is composed of both the vascular
basement membrane (BM) and the interstitial ECM is identified as a crucial component of …

Abstract Background: Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like
protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence …

Abstract Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic
functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic …

The infarcted heart undergoes irreversible pathological remodeling after reperfusion
involving left ventricle dilation and excessive inflammatory reactions in the infarcted heart …

Primary tumors and distant site metastases form a bidirectionally communicating system.
Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified …

The majority of patients with diabetic macular edema (DME), the most common cause of
vision loss in working-age Americans, do not respond adequately to current therapies …

Alterations in ectopic lipid deposition and circulating lipids are major risk factors for
develo** cardiometabolic diseases. Angiopoietin-like protein 4 (ANGPTL4), a protein that …

Integrins are a class of transmembrane receptors that are involved in a wide range of
biological functions. Dysregulation of integrins has been implicated in many pathological …

Mesenchymal stem cells (MSCs) can suppress pathological inflammation. However, the
mechanisms underlying the association between MSCs and inflammation remain unclear …

The traditional view of integrins portrays these highly conserved cell surface receptors as
mediators of cellular attachment to the extracellular matrix (ECM), and to a lesser degree, as …