Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …

The incidence of Alzheimer's disease (AD), the leading cause of dementia, increases rapidly
with age, but why age constitutes the main risk factor is still poorly understood. Brain ageing …

The plasma proteome can help bridge the gap between the genome and diseases. Here we
describe genome-wide association studies (GWASs) of plasma protein levels measured with …

In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …

Alzheimer's disease (AD) is the most prevalent cause of dementia. Although there is no
effective treatment for AD, passive immunotherapy with monoclonal antibodies against …

Triggering receptor expressed on myeloid cells 2 (TREM2) is strongly linked to Alzheimer's
disease (AD) risk, but its functions are not fully understood. Here, we found that TREM2 …

A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …

Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …

Cell-based therapies are being developed for various neurodegenerative diseases that
affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in …