Frailty is a functional status that precedes disability and is characterized by decreased
functional reserve and increased vulnerability. In addition to disability, the frailty phenotype …

This review provides a pulmonary-focused description of the age-associated changes in the
integrative physiology of exercise, including how declining lung function plays a role in …

The introduction of duplex Doppler ultrasound almost half a century ago signified a
revolutionary advance in the ability to assess limb blood flow in humans. It is now widely …

Aging is one of the major non-reversible risk factors for several chronic diseases, including
cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause …

As dysfunction of the vascular system is an early, modifiable step in the progression of many
cardiovascular diseases, there is demand for methods to monitor the health of the vascular …

Objectives—Controversy exists over the effect of acute hyperglycemia on vascular function.
In this systematic review, we compared the effect of acute hyperglycemia on endothelial and …

Background: Oxidative stress is involved in different pathophysiological states, such as
aging, inflammatory, cardiovascular and neurodegenerative diseases, by damaging several …

Increased sitting time, the most common form of sedentary behavior, is an independent risk
factor for all-cause and cardiovascular disease mortality; however, the mechanisms linking …

Drug–drug interaction (DDI) defines a situation in which one drug affects the activity of
another when both are administered together. DDI is a common cause of adverse drug …

Aging is often associated with reduced leg blood flow, increased arterial stiffness, and
endothelial dysfunction, all of which are related to declining nitric oxide (NO) bioavailability …