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Oxidative stress as a key modulator of cell fate decision in osteoarthritis and osteoporosis: a narrative review
During aging and after traumatic injuries, cartilage and bone cells are exposed to various
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …
pathophysiologic mediators, including reactive oxygen species (ROS), damage-associated …
Reactive oxygen species, aging and articular cartilage homeostasis
Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
The role of metabolism in the pathogenesis of osteoarthritis
Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …
Aging and osteoarthritis: central role of the extracellular matrix
Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and develo** world. Increased …
impairment in the aging population across the developed and develo** world. Increased …
Emerging regulators of the inflammatory process in osteoarthritis
Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …
progression. Effective disease-modifying OA therapies are lacking, but better understanding …
[HTML][HTML] Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA
Objective Obesity was once considered a risk factor for knee osteoarthritis (OA) primarily for
biomechanical reasons. Here we provide an additional perspective by discussing how …
biomechanical reasons. Here we provide an additional perspective by discussing how …
A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development
Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis,
a common disease for which no effective disease-modifying therapy currently exists. Here …
a common disease for which no effective disease-modifying therapy currently exists. Here …
Melatonin: A novel candidate for the treatment of osteoarthritis
Y Zhang, T Liu, H Yang, F He, X Zhu - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …
Senescent cells and osteoarthritis: a painful connection
Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …
[HTML][HTML] The implication of reactive oxygen species and antioxidants in knee osteoarthritis
Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential
challenge for public health, with a negative impact on the geriatric patient's quality of life …
challenge for public health, with a negative impact on the geriatric patient's quality of life …