Immune cell trafficking is a complex and tightly regulated process that is indispensable for
the body's fight against pathogens. However, it is also increasingly acknowledged that …

Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial
hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts …

Inflammation is an unstable state. It either resolves or persists. Why inflammation persists
and the factors that define tissue tropism remain obscure. Increasing evidence suggests that …

Introduction Hypoxia is a microenvironmental feature in the inflamed joint, which promotes
survival advantage for cells. The aim of this study was to examine the relationship of partial …

Two major monocyte subsets, CD14+ CD16−(classical) and CD14+/dim
CD16+(nonclassical/intermediate), have been described. Each has different functions …

Stromal cells like synovial fibroblasts gained great interest over the years, since it has
become clear that they strongly influence their environment and neighbouring cells. The …

There is an urgent demand for wound healing biomaterials because of the increasing
frequency of traffic accidents, industrial contingencies, and natural disasters. Borate …

Abstract Knowledge of how the joint functions as an integrated unit in health and disease
requires an understanding of the stromal cells populating the joint mesenchyme, including …

Interactions between lymphocytes and stromal cells have an important role in immune cell
development and responses. During inflammation, stromal cells contribute to inflammation …