Cancer has long been viewed as a genetic disease of cumulative mutations. This notion is
fuelled by studies showing that ageing tissues are often riddled with clones of complex …

Proper regulation of mRNA production in the nucleus is critical for the maintenance of
cellular homoeostasis during adaptation to internal and environmental cues. Over the past …

Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …

Understanding cellular coordination remains a challenge despite knowledge of individual
pathways. The RNA exosome, targeting a wide range of RNA substrates, is often …

A family of structurally related cyclin‐dependent protein kinases (CDKs) drives many
aspects of eukaryotic cell function. Much of the literature in this area has considered …

Abstract Cyclin Dependent Kinases (CDKs) are closely connected to the regulation of cell
cycle progression, having been first identified as the kinases able to drive cell division. In …

The perinucleolar compartment (PNC) was initially identified as a nuclear structure enriched
for the polypyrimidine tract-binding protein. Since then, the PNC has been implicated in …

RNA surveillance systems degrade aberrant RNAs that result from defective transcriptional
termination, splicing, and polyadenylation. Defective RNAs in the nucleus are recognized by …

The cyclin-dependent kinases 12 (CDK12) and 13 (CDK13) govern several steps of gene
expression, including transcription, RNA processing and translation. The main target of …

The spatial co-presence of aberrant long non-coding RNAs (lncRNAs) and abnormal coding
genes contributes to malignancy development in various tumors. However, precise …