Copper (Cu) is a vital element required for cellular growth and development; however, even
slight changes in its homeostasis might lead to severe toxicity and deleterious medical …

This review explores the multifaceted role that iron has in cancer biology. Epidemiological
studies have demonstrated an association between excess iron and increased cancer …

Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Herein, we report the synthesis of eight new mononuclear and binuclear Co2+, Ni2+, Cu2+,
and Zn2+ methoxy thiosemicarbazone (MTSC) complexes aiming at obtaining …

The chemical and biological effects of thiosemicarbazones have received considerable
interest from medicinal chemists for many years. This is attributed to, first, their wide …

Currently, cancer and its progression to metastasis result in a large number of deaths. The
lack of new drugs, appropriate clinical trials for metastasis preventive drugs and incomplete …

Copper homeostasis is tightly regulated in both prokaryotic and eukaryotic cells to ensure
sufficient amounts for cuproprotein biosynthesis, while limiting oxidative stress production …

Thiosemicarbazones and their metal complexes are compounds that possess antitumor,
antibacterial, antifungal and antiviral properties. For the foremost majority of cases the …