Background: Extensive clinical and experimental research documents the potential for
chemical disruption of thyroid hormone (TH) signaling through multiple molecular targets …

Myostatin (MSTN) is a well-reported negative regulator of muscle growth and a member of
the transforming growth factor (TGF) family. MSTN has important functions in skeletal muscle …

Transthyretin amyloid (ATTR) cardiomyopathy is a debilitating disease leading to heart
failure and death. It is characterized by the deposition of extracellular ATTR fibrils in the …

The choroid plexus (ChP) is part of the blood‐cerebrospinal fluid barrier, regulating brain
homeostasis and the brain's response to peripheral events. Its upregulation and …

Abstract The European Commission asked EFSA for a scientific opinion on the risks for
animal and human health related to the presence of chlorinated paraffins in feed and food …

There are more than 30 human proteins whose aggregation appears to cause degenerative
maladies referred to as amyloid diseases or amyloidoses. These disorders are named after …

Transthyretin (TTR) is an extracellular protein mainly produced in the liver and choroid
plexus, with a well-stablished role in the transport of thyroxin and retinol throughout the body …

Background: House dust contains many organic contaminants that can compete with the
thyroid hormone (TH) thyroxine (T 4) for binding to transthyretin (TTR). How these …

This review summarises the current state of knowledge regarding the physiology and control
of production of thyroid hormones, the effects of chemicals in perturbing their synthesis and …

Systemic amyloidosis can be hereditary or acquired with autosomal dominant mutations in
the transthyretin gene (TTR) being the most common cause of hereditary amyloidosis …